What does indomethacin ointment help with?

Ointment Indomethacin is very much in demand in traumatology and orthopedics. Indications for its use are extensive, because the main action is anti-inflammatory and analgesic.

Indomethacin - description of the drug

Indomethacin(Indomethacin ointment 10%, 5%) is designed to relieve fever, inflammation, and eliminate stiffness of movements. The drug of local action is used after injuries, operations, helps to remove swelling. In the form of an ointment, the medicine is produced by different manufacturers:

• "Sopharma";
• "Altfarm";
• "Berlin Chemie";
• "Biosynthesis", etc.

In 1 g of ointment there is 100 mg of the active ingredient - indomethacin. It belongs to the group of NSAIDs, is a derivative of indoacetic acid. The ointment has a yellow, yellow-brown color, homogeneous.

Depending on the manufacturer, additional components may be:

• propylene glycol;
• nipagin;
• urea;
• levomenthol;
• water;
• transcutol R;
• nipazole;
• stearic alcohol;
• cholesterol;
• white wax;
• petrolatum;
• lanolin;
• dimethyl sulfoxide;
• trolamine;
• polyethylene oxide.

The cost of the drug varies from 40 to 90 rubles. Some brands produce the drug of the same name in other forms - tablets, injection, gel, suppositories (rectal suppositories), capsules.

The effect of the ointment on the body

As a derivative of indoleacetic acid, which belongs to non-steroidal anti-inflammatory drugs, indomethacin has a powerful analgesic, anti-inflammatory, antipyretic effect. The mechanism of operation of the drug is based on the inhibition of specific enzymes COX1, COX2.

This leads to inhibition of the production of prostaglandins - hormone-like substances that are mediators of pain and inflammation. They are actively produced by body tissues in the acute inflammatory period. Also the active substance of the ointment:

The drug quickly removes the morning stiffness of the joints, restores mobility. A pronounced effect in the treatment with Indomethacin is observed on the 5-7th day of the course, but the analgesic and anti-inflammatory effect is noticeable literally 30-60 minutes after application. What other effects are there, what does Indomethacin ointment help with? After application, swelling, pain, hyperthermia disappear. The half-life is 4.5 hours, the maximum plasma concentration is after 2 hours. Excreted by the kidneys (60%), intestines (the rest) in the form of metabolites.

Indications for use

The spectrum of indications for Indomethacin is wide. Best of all, he proved himself in diseases of the musculoskeletal system, accompanied by pain, inflammatory reactions:

The drug quickly helps relieve pain with tendonitis - inflammation of the tendon. It is recommended to reduce pain and after traumatic lesions of the joints, bones, vertebrae.

In case of injury, the medicine will remove swelling, inflammation, and reduce pain.

Indomethacin is indicated to reduce pain in benign, malignant tumors of the vertebrae and joints. It is also used during stenosis of the spinal canal, after operations, with muscle pain, muscle strain, thrombophlebitis, neuralgia. In gynecology and a number of other areas of medicine, Indomethacin is prescribed in tablets.

Instructions for use

Depending on what Indomethacin ointment is used for, the order, timing, and frequency of its application may change. The tool is recommended to be used in complex therapy, because its action is local. From arthritis, arthrosis, osteochondrosis, ointment is applied to the problem area 3-4 times / day. Easily rub the ointment, leave until absorbed, without covering with clothes. The course of therapy is 7-10 days.

If there is no effect from therapy for the specified period, it is better to consult a doctor for additional studies or other recommendations.

Special instructions for the use of the ointment are as follows:

1. The amount of ointment 5% for an adult is approximately 2-3 cm for one affected area. It can be one joint, one section of the spine, etc. For small joints, the amount of the product is reduced.
2. The dosage of the drug is 5% for children from 6 years old - up to 1.5 cm, for babies from a year old, the dosage is selected only by a doctor.
3. Ointment with a concentration of indomethacin 10% is used in adults in the same way, but 2-3 times / day, not more often.
4. The maximum amount of ointment applied to the body in adults per day should not be more than 15 cm, in children from 6 years old - 7 cm.

The duration of the course of treatment in children is up to 5-7 days. Do not rub the drug into the area of ​​open wounds, allow contact with the eyes, mucous membranes. During pregnancy, according to strict indications, it is allowed to use the ointment, but only in 1-2 trimesters. It is recommended even during this period to replace Indomethacin with a more gentle remedy.

Contraindications ointment Indomethacin

A strict contraindication is the presence of severe allergic and other systemic reactions after using this group of NSAIDs in history. Also contraindications are:

• ulcers, erosion of the stomach, duodenum;
• serious bleeding disorders;
• severe degree of renal, hepatic insufficiency;
• heart failure - decompensated form;
• "Aspirin" bronchial asthma.

Local prohibitions are wounds, non-healing ulcers, and other types of violation of the integrity of the skin.

Also, you can not use the remedy for acute dermatitis, eczema, abscesses in any form.

Indomethacin should not be used for degenerative lesions of the hip joint.

Pregnant women use the ointment only under the close supervision of a physician. With lactation, treatment should be abandoned, or feeding should be interrupted for the period of therapy. The drug is strictly prohibited for children under one year old, from a year to 6 years old, therapy is carried out under the supervision of a pediatrician. With caution, they are treated with hypertension, hemorrhoids, pancreatitis, pathologies of the optic, auditory nerve.