Who can drink Nimesil? Method of application and features of action on the body

Nimesil has established itself as one of the most highly effective agents among non-steroidal anti-inflammatory drugs (NSAIDs). In order to fully evaluate the effect of the drug and avoid negative consequences for, you need to use it, taking into account a number of features and contraindications.

All about Nimesil

The drug is available in the form of an orange-scented powder with a granular structure. It includes:

• Nimesulide
• Ketomacrogol 1000
• Maltodextrin
• Anhydrous citric acid
• Flavor "orange"

The main spectrum of action of the drug is aimed at lowering the temperature, eliminating inflammation and pain relief. This drug is intended to relieve symptoms at the time of use, but it is also used for long-term therapy. The effect of the drug is felt in the first hour after ingestion, and its effect is extended for a period of up to 6 hours.

Nimesil is prescribed for:

• Headaches, toothaches, cramps during menstruation, pain syndromes after injuries, with rheumatism
• Inflammatory and infectious diseases
• Inflammatory and degenerative processes in the musculoskeletal system in diseases of arthritis, osteochondrosis, sciatica
• Vascular diseases, urological and gynecological diseases
• High

For one application, it is enough to dilute the contents of the drug sachet in half a glass of water. The resulting solution is drunk after meals. The drug can be taken no more than twice a day.

Children under 12 years of age are prohibited from taking the drug. Adolescents from 12 years old and adults drink a solution of the drug in equal doses. The exception is the elderly, who need to combine the intake of several drugs. In their case, the optimal amount of medication is determined by the attending physician.

The course of treatment with the drug should not exceed 15 days. To exclude the development of side effects, it is recommended to take it in minimal quantities and for a short time.

Side effects associated with the medication

Problems when taking the drug are often associated with unaccounted for individual intolerance and dosage violations, the duration of the course usually does not affect the manifestation of side effects, which include:

• Disorder of the central nervous system, expressed in headaches, drowsiness, unreasonable fear and nightmares
• Cardiovascular problems (tachycardia, hemorrhage, hypertension) are rare but not excluded
• Disorders of the digestive system, manifested in the form of: nausea, vomiting, flatulence, constipation or gastritis
• Visual impairment
• Bronchospasm or
• Skin itching, redness
• Increased levels of liver enzymes in the blood
• A disorder of the urinary system associated with urinary retention or excess blood in the urine
• Violation of the process of blood formation

The wrong dosage of a drug can negatively affect almost any system of the body.

In what cases is the drug prohibited?

There are a number of situations and diseases in which the use of the drug can lead to complications or exacerbation of diseases:

• Hypersensitivity to the components of the preparation
• Hyperergic and hepatotoxic reactions in the history of the disease to nimesulide and other drugs from the group of non-steroidal anti-inflammatory drugs
• The combination of taking Nimesil with drugs, such as paracetamol and other analgesics, which can have a negative effect on the structural and functional state of the liver
• Inflammation of the intestines in the acute phase
• In the period after surgery to restore blood flow in the arteries of the heart with the help of shunts.
• Fever with colds
• Liver disease
• dependence on alcohol or

Along with other drugs from the NSAID group, Nimesil can adversely affect the course of pregnancy and fetal development. Treatment with this drug during the period of bearing a child or feeding it is fraught with:

• Premature closure of the ductus arteriosus
• Disorders in work that can progress to kidney failure
• An increased risk of bleeding
• Decreased ability of the uterus to contract

These problems jeopardize the development of the fetus and its proper formation, so pregnant or lactating women are prohibited from using the drug.

The doctor prescribes the drug after a thorough assessment of the risks and benefits of its use.

Side effects from the use of the drug are minimized by reducing the dose and treatment in the shortest possible time.

For those who have been diagnosed with ulcerative colitis or Crohn's disease, the minimum effective dose of the drug is prescribed to avoid exacerbation of these diseases.

The occurrence of bleeding in the gastrointestinal tract, ulcers, or the appearance of a through defect in the wall of the stomach or duodenum is possible in those who have previously encountered peptic ulcers, as well as in the elderly. These groups of patients are prescribed the drug in minimal effective doses or completely excluded from taking it, as it reduces blood clotting and increases the risk of bleeding.

Depending on the level of urination and the severity of problems with the functioning of the kidneys, the dosage of the drug is reduced as much as possible, since the drug is partially excreted from the body through the kidneys.

In the treatment of the drug in some cases, there were negative reactions from the side of the liver. Sometimes there is skin itching, yellowness of the skin and mucous membranes, vomiting and abdominal cramps are disturbing. In the presence of these symptoms, the use of the drug is immediately stopped and consult a doctor.

Visual impairment when taking anti-inflammatory non-steroidal drugs and specifically Nimesil is a rather rare occurrence, but if it occurs, an immediate appeal to an ophthalmologist is required.

Caution should be taken when taking the drug for people with diseases of the cardiovascular system and hypertension, since Nimesil can lead to fluid retention in the tissues.

Those who have diabetes or follow a low-calorie diet should pay attention to the sugar content in the preparation. Nimesil is prohibited for people with fructose intolerance. During the course of treatment with the drug, there may be signs of a cold. If these have been diagnosed, then you should immediately stop taking the drug.

When prescribing a drug, elderly people require constant clinical monitoring, since in their case there is a high risk of developing bleeding in the gastrointestinal tract, impaired functioning of the liver, kidneys, or.

Nimesil can adversely affect a woman's ability to conceive a child, so it is not recommended for women planning a pregnancy.

The drug should not be used together with other drugs from the group of non-steroidal anti-inflammatory drugs or together with alcohol.

Skin reactions are a very rare side effect when taking Nimesil, however, if allergic reactions, skin rashes appear, the use of the drug is stopped.

Studies aimed at studying the effect of the drug on the control of complex mechanisms have not been officially studied. Accordingly, it is necessary to sensibly assess your condition before carrying out activities that require maximum concentration and speed of reaction.

The presence of diseases suggests a decrease in the dose of Nimesil.

Interaction with other drugs and their components

Use with steroidal hormonal anti-inflammatory drugs can lead to gastric or duodenal ulcers, bleeding. Simultaneous treatment with drugs that prevent adhesion and platelet aggregation, together with Nimesil, can cause bleeding in the gastrointestinal tract.

Combining a course of treatment with taking drugs that prevent clotting and the formation of blood clots, such as warfarin or acetylsalicylic acid, is contraindicated in severe coagulation disorders.

Non-steroidal anti-inflammatory drug reduces the activity of diuretics. In people with reduced kidney function, when taking ACE inhibitors and Nimesil at the same time, further deterioration in kidney function is likely, which can lead to acute renal failure, in most cases reversible. During the joint administration of such drugs, it is necessary to carefully control the amount of fluid consumed and the work of the kidneys, especially when it comes to the elderly.

Numesulide reduces the effect of the diuretic Furosemide in relation to the excretion of Na and, to a lesser extent, to the excretion of K, reduces the diuretic effect. The combination of these drugs requires increased attention in case of problems with the heart or kidneys.

The use of anti-inflammatory nonsteroidal drugs leads to an increase in the level of lithium in the blood and, accordingly, an increase in its toxicity. When treating with drugs containing lithium and taking Nimesil, control of the element in the blood plasma is required.

Numesulide inhibits the activity of the CYP 2C9 enzyme. When combined with taking drugs that are a substrate of this enzyme, together with Nimesil, their concentration in the blood may increase.

The drug should be taken with caution in combination with other drugs.

Nimesil's analogs

Nimesil has a number of analogues that have a number of significant advantages. They have fewer contraindications and some are approved for treatment to treat young children. The best among these medicines are:

• Aponil. Produced in the form of tablets. 1 tablet contains 100 mg of nimesulide. For a day, an adult can drink - 400 mg, for one application it is allowed to use no more than 200 mg. Children under 12 years of age are prescribed the drug in an amount calculated for each kilogram of weight. The maximum daily dose is 100 mg.
• Nise. It is produced in the form of tablets, suspension or gel. In the first case, for adults, the daily rate is 200 mg and the maximum is 400 mg, the intake is divided into two times. If there are diseases of the gastrointestinal tract, then you need to drink the drug after eating. For children over 12, the daily rate is prescribed depending on weight, for each kilogram of 1.5 mg of medication. The drug should be divided into 3 times.
• it is drunk 2 times a day, 100 mg after meals, the course of treatment lasts no more than 10 days. For children older than two years, the dose is calculated by weight, taking 5 mg for each kilogram. The medicine is given no more than three times a day.
• The gel is applied without rubbing on pre-cleansed skin in the area of ​​the painful area up to 4 times a day. The maximum daily dose is 30 g. The duration of gel treatment is 10 days.
• Nimulid. Produced in the form of tablets, powder and gel. In the first case, adults are prescribed two daily doses of the drug, 1 tablet or 1 sachet dissolved in 100 ml of water. The gel form of the drug is applied in the same way as the Nise gel.

Aponil is considered less effective than the other analogues presented.

While watching the video, you will learn about taking Nimesil.

Nimesil effectively and quickly affects the body, eliminating pain, lowering the temperature and reducing inflammation, however, it has a number of serious contraindications. People who have problems with the stomach or intestines, heart or kidneys should consult their doctor before using this drug.